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The present clinical investigation attempts to address limitations in the field by infusing cortisol rather than a synthetic corticosteroid as the negative-feedback signal; studying older subjects in whom sex differences under a gonadal-steroid clamp may be more prominent; experimentally controlling the sex-steroid milieu; sampling every 10 min for 8 h; employing equal-dose cortisol infusions in pulses or continuously so as to compare a putatively physiological (pulsatile) versus pharmacological (continuous) feedback pattern; calculating free cortisol from albumin and cortisol binding globulin (CBG) concentrations; and applying deconvolution analysis to estimate pulsatile ACTH secretion and ACTH approximate entropy (ApEn) as a model-free measure of feedback strength, what's best steroid cycle. Older individuals were studied since sex differences in ACTH responses may be greater and/or more consistent in older than young humans (reviewed in Ref. 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